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When running my pickups in parallel, they are noticably "thicker" like most people describe them sounding (it's more complex than that, but like you said it's hard to describe sounds over the internet).
I rarely ever run them in parallel, but I've gotten some pretty cool jazzy type sounds when I have...I just don't really play that style often.
The bridge pickup (which mine isn't a humbucker) is the only one I'll use in parallel with any amount of overdive, the neck and middle pickups are usually just too muddy with overdriven tones. If I had to pick one or the other it'd be series.
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