Call it laziness if you will (or lack of mental capacity!! I am getting older!!) but I made the call a few years ago that all of my guitars had to be 22 fret (where it is sensible - I agree with tonyw) so I didn't have to think about fret positions too much. I do find that because the 21 and 22 fret Strat necks are essentially the same dementions my hand will automatically got to the correct area of the neck regardless (eg the 12th fret is the same 'feel' place on both necks). Gibsons, etc follow much the same 'feel' pattern. I have a 24 fret PRS copy and I find that where I 'feel' the 12th fret would be on a Strat is around the 16th fret on it, and it throws me every time. Man! I have to concentrate to play that thing! 21 or 22 fret is not a biggie, but I like to keep things simple where I can. A different feel and a different sound can inspire me, so it doesn't have to be a bad thing. I agree with Strato - that why we need more than one guitar!