I'm probably a little late to the game, but here's my two cents worth, and this is a variation on
it's all in the player's hands;
Assuming the usual set-up, (with proper low action and intonation adjusted appropriately), the greatest tone difference you can enjoy can be found in simply exploring and using the Stratocaster's Controls (pickup selector switch, Volume and Tone knobs) to their full advantage.
Most performers set the Volume and Tone knobs to a particular setting, set the five-way selector switch to their favored pickup position, and then play the entire song or set pretty much that way.
The reality is that there are enormous tonal differences that can, and should, be made on the fly, during the performance of each song.
Watch any experienced gigging musician.
They tend to flip from this pickup position to another, to make the guitar cut thru the mix better, or soften up the bite even.
They'll make subtle Tone knob refinements, sometime two or three times in one performance.
They'll roll the Volume knob up slightly to get more bark, or roll it down just a bit, to even out the bark.
I can't find it right now, but Joe Bonamassa filmed a pretty good video of himself seated with a guitar (it was a Les Paul of course, but the fundamentals are there), and he demonstrated a wide variety of sonic magic you can make without pedals and without effects, just by going for the right selectors switch, Volume, and Tone adjustments.
Okay, I'm gonna shut up now.

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