My Tele had steel block saddles when I got it. Switching to brass 3 barrel saddles made a big difference for me. A bigger and more obvious difference than most of the pickup swaps I've ever done. The brass saddles add something to the sound that reminds me of bronzewound strings, that totally wasn't there before. If I was gonna try to get a Tele sound out of a Strat, I would absolutely use barrel saddles (compensated, I still want the sucker to intonate). Installation would require drilling holes in the bridge plate.